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Vascular Permeability

Data collected in our laboratories combined with other data reveal interdependency between solubility and permeability measured through the skin of Sprague-Dawley rats [1415]. These results are obtained from fusion of transdermal H2S measurements with data on other molecules collected previously. There is clearly an inverse linear relationship between water solubility and permeability, which implies a direct linear relationship between lipid solubility and permeability as reported by others [16].  Acetone, with a higher water solubility than H2S, is predicted to have more than an order-of-magnitude lower permeability through lipophilic layers. This information is being used for measurement of vascular permeability, as it relates to a number of health problems such as respiratory disorders and lung cancer.