Dynamic Breath Acetone Measurements Linked to Diabetes

At the University of Cincinnati (UC), our research partners have demonstrated that exposing Nafion membrane containing immobilized resorcinol molecules to dry or wet acetone vapor at sub-ppm levels produces an orange-colored compound [11] and [12]. This colored flavan compound formed from acetone and resorcinol allows selective, sensitive, and rapid detection of acetone. This technique has been used in collaboration with UC College of Medicine for breath analysis of healthy individuals and patients suffering from diabetes mellitus.  As predicted, there is a linear increase in exhaled acetone (see Figure) which correlates to blood glucose concentration, serving as a non-invasive measure of blood acetone concentrations [13].